The I helix and oxygen binding site

The long I helix has a kink in it at Thr 252 which makes a small cavity in which oxygen is thought to bind. Asp 251 is on the I-helix. Van der Waals contacts are made between the substrate and residues in the I-helix.

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Wade et al. (1996) Fundamentals of Enzyme-Ligand Interactions in Cytochrome P450cam
POPE5 Conference Proceedings
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