main literature:
B.A. Katz et al. (2003) Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors. J. Mol. Biol. 329:93-120.

B.A. Katz et al. (2001) A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J. Mol. Biol. 307:1451-1486.

E. Verner et al. (2001) Development of serine protease inhibitors displaying a multicentered short (2.3 A) hydrogen bond binding mode: Inhibitors of urokinase-type plasminogen activator and factor Xa. J. Med. Chem. 44:2753-2771. Supplement.

B.A. Katz et al. (2001) Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chemistry Biology 8:1107-1121.

B.A. Katz et al. (1998) Design of potent selective zinc-mediated serine protease inhibitors. Nature 391: 608-612.

further literatur:
B.A. Katz et al. (2000) Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chemistry Biology 7:299-312.

B.A. Katz et al. (2002) Contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors. J. Am. Chem. Soc. 124:11657-11668.

B.A. Katz et al. (1995) Episelection: Novel Ki ~ nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry 34:8264-8280.

W.D. Shrader et al. (2001) Neutral inhibitors of the serine protease factor Xa. Bioorg. Med. Chem. Let. 11:1801-1804.

J.R. Spencer et al. (2002) 4-aminoarzlguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Bioorg. Med. Chem. Let. 12:2023-2026.

R. Rai et al. (2001) Development of potent and selective factor Xa inhibitors. Bioorg. Med. Chem. Let. 11:1797-1800.

R.L. Mackman et al. (2002) 2-(2-hydroxy-3-alkoyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urakinase-type plasminogen activator inhibitors. Bioorg. Med. Chem. Let. 12:2019-2022.

W.B. Young et al. (2001) Optimization of a screening lead for factor VIIa/TF. Bioorg. Med. Chem. Let. 12:2253-2256.

update: 06.09.2004