Links for structure and ligand searches

Protein structures

Small molecules

Search tools for protein data

Sequence Alignment

Programs

Documentation

Links


Programs for working with ligands

Programs



Protein structures

RCSB Protein Data Bank
http://www.rcsb.org/pdb/index.html
Database for protein and DNA structures.

PDBsum
http://www.ebi.ac.uk/thornton-srv/databases/pdbsum
Browser for the Protein Data Bank.

Electron Density Server at Uppsala University
http://eds.bmc.uu.se/eds/
Loading electron densities of structures of PDB.

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Small molecules

HIC-Up
http://alpha2.bmc.uu.se/hicup/
Database of small molecules of the Hetero-compound Information Centre in Uppsala.

Cambridge Structural Database (CSD)
http://www.ccdc.cam.ac.uk/products/csd/
Small molecule crystal structures.

Dundee PRODRG2 Server
http://davapc1.bioch.dundee.ac.uk/programs/prodrg/
Generating parameter files (GROMOS, GROMACS, WHAT IF, REFMAC5, CNS, O, SHELX, HEX and MOL2) for small molecules.

Ligand Depot - Substructure Search
http://ligand-depot-i.rutgers.edu/html/sketch.html
http://ligand-depot-i.rutgers.edu/html/index.html
Sketch a fragment of a ligand and search for it.

Macromolecular Structure Database (MSD) - Ligand Chemistry
http://www.ebi.ac.uk/msd-srv/chempdb/cgi-bin/cgi.pl

Protein Ligand Database
http://www-mitchell.ch.cam.ac.uk/pld/

Ligand.Info

http://ligand.info/
Java-based tool: http://ligand.info/applet.html
Ligand.Info is a compilation of various publicly available databases of small molecules such as ChemBank, ChemPDB, KEGG, NCI, AKos GmbH, and Asinex Ltd. The total size of the Meta-Database is 1 million entries.

ChemBank
http://chembank.med.harvard.edu/
Compound Search: http://chembank.med.harvard.edu/compounds/
ChemBank is a freely available collection of data about small molecules and resources for studying their properties, especially their effects on biology.

KiBank
http://kibank.iis.u-tokyo.ac.jp/index.jsp
KiBank for in silico drug design. This database contains binding affinity, structures of chemicals and target proteins, and many useful links and information.

Binding Databse

http://www.bindingdb.org/bind/index.jsp
The BindingDB is a public, web-accessible database of measured binding affinities for biomolecules, genetically or chemically modified biomolecules, and synthetic compounds.

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Search tools for protein data

BRENDA
http://www.brenda.uni-koeln.de/
personal login: http://www.brenda.uni-koeln.de/logreg/login
Comprehensive Enzyme Information System.

Tadpole
http://uranos/sci_sw/Tadpole_1.2.9/index.html
Tool for automated protein data retrieval.

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Sequence Alignment

Indonesia
http://xray.bmc.uu.se/dennis/
Program from the Biomedical Centre in Uppsala for structure-based sequence alignments. Java-based program which can read pdf-file for superimposing the structures and creating a sequence alignment in various file-formats.
For starting the program: prepare indonesia / indonesia

Interactive Editor for Multiple Sequence Alignments STRAP
http://www.charite.de/bioinf/strap/
Start:
/sw/mcm/app/java/jre1.5.0/javaws/javaws
http://www.charite.de/bioinf/strap/strap2.jnlp

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Programs

CORINA
http://www.mol-net.de/software/corina/index.html
Generation of 3D coordinates.

GOLD
http://gold.ccdc.cam.ac.uk/index.php
GOLD Interactive Web Trial

http://www.ccdc.cam.ac.uk/products/life_sciences/gold/
GOLD is a program for calculating the docking modes of small molecules into protein binding sites.

insightII
Insight II can add hydrogens to ligands at different pH-values.

Marvin
http://www.chemaxon.com/marvin/
MarvinSketch and MarvinView for eg. SDF-files

MolProbity
http://kinemage.biochem.duke.edu/molprobity/index-king.html
MolProbity is a graphical user interface to many of the macromolecule structure analysis and validation programs produced in the Richardson Lab at Duke University.

OpenEye Scientific Software
http://www.eyesopen.com/

Quac Pac

http://www.eyesopen.com/products/applications/quacpac.html
May be usefull for calculating protonation state? Licence required!

Reduce
http://kinemage.biochem.duke.edu/software/reduce.php
Reduce is a program for adding hydrogens to a Protein DataBank (PDB) molecular structure file.

Vida
http://www.eyesopen.com/products/applications/vida.html
/home/gabdourf/progs/VIDANC6
source env.com
Doesn't add hydrogens to a pdb file in the right way without any further information (atomtypes, bonds, hybrydisation,...)

WatCH
http://www.bch.msu.edu/labs/kuhn/web/software/WatCH/doc.html
A tool for identifying conserved water sites and analyzing their degree of conservation using heirarchical cluster analysis of superimposed related Protein Data Bank structures.

WHATIF
http://swift.cmbi.kun.nl/whatif/
http://swift.cmbi.kun.nl/whatif/toc.html

Pro-Flex

XDrawChem 1.5

PDB2PQR



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Documentation

GOLD
GOLD 2.2


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Links

Links to various programs
http://www.clarku.edu/faculty/mlei/chem_link.htm

U.S. Environmental protection Agency

http://www.epa.gov/nheerl/dsstox/Glossary.html
SMILES http://www.epa.gov/nheerl/dsstox/MoreonSMILES.html


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