| PDB ID |
Experimental Technique |
Title |
Chain Identifier |
Chain Length |
pH Value |
R Value |
Resolution [Å] |
Authors |
First Page |
Journal Name |
Volume No |
Publication Year |
| 1A0J
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF A NON-PSYCHROPHILIC TRYPSIN FROM A COLD-ADAPTED FISH
SPECIES. |
A |
223 |
4.600 |
0.173 |
1.700 |
H.K.Schroder,
N.P.Willassen, A.O.Smalas |
780 |
Acta
Crystallogr D Biol Crystallogr |
54 |
1998 |
| B |
223 |
| C |
223 |
| D |
223 |
| 1AQ7
|
X-RAY
DIFFRACTION |
TRYPSIN
WITH INHIBITOR AERUGINOSIN 98-B |
n/a |
223 |
8.500 |
0.164 |
2.200 |
B.Sandler,
M.Murakami, J.Clardy |
595 |
J
Am Chem Soc |
120 |
1998 |
| 1AUJ
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR |
n/a |
223 |
6.600 |
0.169 |
2.100 |
S.L.Lee,
R.S.Alexander, A.Smallwood, R.Trievel, L.Mersinger, P.C.Weber, C.Kettner |
13180 |
Biochemistry |
36 |
1997 |
| 1AZ8
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN COMPLEXED TO BIS-PHENYLAMIDINE INHIBITOR |
n/a |
223 |
8.200 |
0.188 |
1.800 |
R.Alexander,
T.Maduskuie, K.Mcnamara, A.Smallwood, A.Wei, P.Stouten |
n/a |
To
be Published |
n/a |
n/a |
| 1BIT
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURE OF ANIONIC SALMON TRYPSIN IN A SECOND CRYSTAL FORM |
n/a |
237 |
n/a |
0.199 |
1.830 |
G.I.Berglund,
A.O.Smalas, A.Hordvik |
725 |
Acta
Crystallogr D Biol Crystallogr |
51 |
1995 |
| 1BJU
|
X-RAY
DIFFRACTION |
BETA-TRYPSIN
COMPLEXED WITH ACPU |
n/a |
223 |
6.500 |
0.171 |
1.800 |
S.Presnell,
G.Patil, J.Conley, C.Mura, K.Jude, J.Bertrand, J.Powers, L.Williams |
n/a |
To
be Published |
n/a |
n/a |
| 1BJV
|
X-RAY
DIFFRACTION |
BETA-TRYPSIN
COMPLEXED WITH APPU |
n/a |
223 |
6.500 |
0.196 |
1.800 |
S.R.Presnell,
G.Patil, C.Mura, K.Jude, J.Conley, J.A.Bertrand, C.-M.Kam, J.C.Powers,
L.D.Williams |
n/a |
To
be Published |
n/a |
n/a |
| 1BTH
|
X-RAY
DIFFRACTION |
STRUCTURE
OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR |
H |
259 |
n/a |
0.196 |
2.300 |
A.van
de Locht, W.Bode, R.Huber, B.F.Le Bonniec, S.R.Stone, C.T.Esmon,
M.T.Stubbs |
2977 |
EMBO
J |
16 |
1997 |
| J |
36 |
| K |
259 |
| L |
36 |
| P |
58 |
| Q |
58 |
| 1BTP
|
X-RAY
DIFFRACTION |
UNIQUE
BINDING OF A NOVEL SYNTHETIC INHIBITOR,
N-[3-[4-[4-(AMIDINOPHENOXY)-CARBONYL]PHENYL]-2-METHYL-2-PROPENOYL]-N-ALLYLGLYCINE
METHANESULFONATE TO BOVINE TRYPSIN, REVEALED BY THE CRYSTAL STRUCTURE
OF THE COMPLEX |
n/a |
229 |
n/a |
0.176 |
2.200 |
Y.Odagaki,
H.Nakai, K.Senokuchi, M.Kawamura, N.Hamanaka, M.Nakamura, K.Tomoo,
T.Ishida |
12849 |
Biochemistry |
34 |
1995 |
| 1BTW
|
X-RAY
DIFFRACTION |
EPISELECTION:
NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING
OR CHEMISTRY ON AN ENZYME SURFACE |
A |
229 |
n/a |
0.164 |
1.800 |
B.A.Katz,
J.Finermoore, R.Mortezaei, D.H.Rich, R.M.Stroud |
8264 |
Biochemistry |
34 |
1995 |
| H |
5 |
| 1BTX
|
X-RAY
DIFFRACTION |
EPISELECTION:
NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING
OR CHEMISTRY ON AN ENZYME SURFACE |
A |
229 |
n/a |
0.140 |
1.800 |
B.A.Katz,
J.Finer-Moore, R.Mortezaei, D.H.Rich, R.M.Stroud |
8264 |
Biochemistry |
34 |
1995 |
| H |
4 |
| 1BTY
|
X-RAY
DIFFRACTION |
EPISELECTION:
NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING
OR CHEMISTRY ON AN ENZYME SURFACE |
n/a |
229 |
n/a |
0.161 |
1.500 |
B.A.Katz,
J.Finer-Moore, R.Mortezaei, D.H.Rich, R.M.Stroud |
8264 |
Biochemistry |
34 |
1995 |
| 1BTZ
|
X-RAY
DIFFRACTION |
EPISELECTION:
NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING
OR CHEMISTRY ON AN ENZYME SURFACE |
A |
229 |
n/a |
0.134 |
2.000 |
B.A.Katz,
J.Finer-Moore, R.Mortezaei, D.H.Rich, R.M.Stroud |
8264 |
Biochemistry |
34 |
1995 |
| H |
5 |
| 1C1N
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
5.110 |
0.186 |
1.400 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C1O
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
4.980 |
0.199 |
1.400 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C1P
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
5.900 |
0.178 |
1.370 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C1Q
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
8.210 |
0.174 |
1.370 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C1R
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
8.200 |
0.197 |
1.370 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C1S
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
6.100 |
0.185 |
1.630 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C1T
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
8.180 |
0.174 |
1.370 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2D
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
9.930 |
0.193 |
1.650 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2E
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
9.000 |
0.179 |
1.650 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2F
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
8.000 |
0.190 |
1.700 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2G
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
7.000 |
0.158 |
1.650 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2H
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
6.040 |
0.186 |
1.400 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2I
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
5.500 |
0.177 |
1.470 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2J
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
7.060 |
0.189 |
1.400 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2K
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
3.850 |
0.202 |
1.650 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2L
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
4.860 |
0.195 |
1.500 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C2M
|
X-RAY
DIFFRACTION |
RECRUITING
ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
A |
223 |
4.980 |
0.195 |
1.400 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1C5L
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
H |
259 |
8.200 |
0.215 |
1.470 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| I |
10 |
| L |
36 |
| 1C5N
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
H |
259 |
7.500 |
0.220 |
1.500 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| I |
10 |
| L |
36 |
| 1C5O
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
H |
259 |
7.500 |
0.200 |
1.900 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| I |
11 |
| L |
36 |
| 1C5P
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
7.500 |
0.197 |
1.430 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C5Q
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
8.200 |
0.197 |
1.430 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C5R
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
5.500 |
0.192 |
1.470 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C5S
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
8.200 |
0.197 |
1.360 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C5T
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
8.200 |
0.176 |
1.370 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C5U
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
5.500 |
0.181 |
1.370 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C5V
|
X-RAY
DIFFRACTION |
STRUCTURAL
BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR
INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
A |
223 |
7.720 |
0.198 |
1.480 |
B.A.Katz,
R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang,
H.Chan, L.Wong |
299 |
Chem.Biol. |
7 |
2000 |
| 1C9T
|
X-RAY
DIFFRACTION |
COMPLEX
OF BDELLASTASIN WITH BOVINE TRYPSIN |
A |
223 |
5.600 |
0.208 |
3.300 |
U.Rester,
W.Bode, M.Moser, M.A.Parry, R.Huber, E.Auerswald |
93 |
J.Mol.Biol. |
293 |
1999 |
| B |
223 |
| C |
223 |
| D |
223 |
| E |
223 |
| F |
223 |
| G |
59 |
| H |
59 |
| I |
59 |
| J |
59 |
| K |
59 |
| L |
59 |
| 1CA0
|
X-RAY
DIFFRACTION |
BOVINE
CHYMOTRYPSIN COMPLEXED TO APPI |
A |
13 |
4.500 |
0.215 |
2.100 |
A.J.Scheidig,
T.R.Hynes, L.A.Pelletier, J.A.Wells, A.A.Kossiakoff |
1806 |
Protein
Sci |
6 |
1997 |
| B |
131 |
| C |
97 |
| D |
54 |
| F |
13 |
| G |
131 |
| H |
97 |
| I |
54 |
| 1CBW
|
X-RAY
DIFFRACTION |
BOVINE
CHYMOTRYPSIN COMPLEXED TO BPTI |
A |
13 |
7.500 |
0.192 |
2.600 |
A.J.Scheidig,
T.R.Hynes, L.A.Pelletier, J.A.Wells, A.A.Kossiakoff |
1806 |
Protein
Sci |
6 |
1997 |
| B |
131 |
| C |
97 |
| D |
58 |
| F |
13 |
| G |
131 |
| H |
97 |
| I |
58 |
| 1CE5
|
X-RAY
DIFFRACTION |
BOVINE
PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZAMIDINE |
A |
223 |
6.000 |
0.161 |
1.900 |
N.Ota,
C.Stroupe, J.M.S.Ferreira-Da-Silva, S.S.Shah, M.Mares-Guia, A.T.Brunger |
641 |
Proteins:
Struct., Funct., Genet. |
37 |
1999 |
| 1CGH
|
X-RAY
DIFFRACTION |
HUMAN
CATHEPSIN G |
A |
224 |
7.000 |
0.190 |
1.800 |
P.Hof,
I.Mayr, R.Huber, E.Korzus, J.Potempa, J.Travis, J.C.Powers, W.Bode |
5481 |
EMBO
J |
15 |
1996 |
| S |
4 |
| 1CGI
|
X-RAY
DIFFRACTION |
THREE-DIMENSIONAL
STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN A AND TWO
RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR
(KAZAL-TYPE) |
E |
245 |
n/a |
0.195 |
2.300 |
H.J.Hecht,
M.Szardenings, J.Collins, D.Schomburg |
711 |
J
Mol Biol |
220 |
1991 |
| I |
56 |
| 1CGJ
|
X-RAY
DIFFRACTION |
THREE-DIMENSIONAL
STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN A AND TWO
RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR
(KAZAL-TYPE) |
E |
245 |
n/a |
0.195 |
2.300 |
H.J.Hecht,
M.Szardenings, J.Collins, D.Schomburg |
711 |
J
Mol Biol |
220 |
1991 |
| I |
56 |
| 1CO7
|
X-RAY
DIFFRACTION |
R117H
MUTANT RAT ANIONIC TRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN
INHIBITOR (BPTI) |
E |
245 |
8.500 |
0.208 |
1.900 |
G.F.Stamper,
D.Ringe, L.Hedstrom |
n/a |
Unpublished |
n/a |
n/a |
| I |
99 |
| 1CPX
|
X-RAY
DIFFRACTION |
BETA
FORM OF CARBOXYPEPTIDASE A (RESIDUES 3-307) FROM BOVINE PANCREAS IN AN
ORTHORHOMBIC CRYSTAL FORM WITH TWO ZINC IONS IN THE ACTIVE SITE. |
A |
307 |
7.500 |
0.167 |
2.000 |
J.T.Bukrinsky,
M.J.Bjerrum, A.Kadziola |
16555 |
Biochemistry |
37 |
1998 |
| 1D6R
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF CANCER CHEMOPREVENTIVE BOWMAN-BIRK INHIBITOR IN TERNARY
COMPLEX WITH BOVINE TRYPSIN AT 2.3 A RESOLUTION. STRUCTURAL BASIS OF
JANUS- FACED SERINE PROTEASE INHIBITOR SPECIFICITY |
A |
223 |
8.000 |
0.152 |
2.300 |
J.Koepke,
U.Ermler, E.Warkentin, G.Wenzl, P.Flecker |
477 |
J.Mol.Biol. |
298 |
2000 |
| I |
58 |
| 1EAW
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF THE MTSP1 (MATRIPTASE)-BPTI (APROTININ) COMPLEX |
A |
241 |
8.000 |
0.199 |
2.930 |
R.Friedrich,
W.Bode |
n/a |
To
be Published |
n/a |
n/a |
| B |
58 |
| C |
241 |
| D |
58 |
| 1EB1
|
X-RAY
DIFFRACTION |
COMPLEX
STRUCTURE OF HUMAN THROMBIN WITH N-METHYL-ARGININE INHIBITOR |
n/a |
3 |
8.000 |
0.191 |
1.800 |
R.Friedrich,
T.Steinmetzer, W.Bode |
n/a |
To
be Published |
n/a |
n/a |
| A |
10 |
| H |
257 |
| L |
27 |
| 1EB2
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR COMPLEX (BPO) |
A |
223 |
8.150 |
0.178 |
2.000 |
J.W.Liebeschuetz,
S.D.Jones, P.J.Morgan, C.W.Murray, A.D.Rimmer, J.M.E.Roscoe,
B.Waszkowycz, P.M.Welsh, W.A.Wylie, S.C.Young, H.Martin, J.Mahler,
L.Brady' K.Wilkinson |
n/a |
To
be Published |
n/a |
n/a |
| 1EJA
|
X-RAY
DIFFRACTION |
STRUCTURE
OF PORCINE TRYPSIN COMPLEXED WITH BDELLASTASIN, AN ANTISTASIN-TYPE
INHIBITOR |
A |
223 |
7.700 |
0.191 |
2.700 |
U.Rester,
M.Moser, R.Huber, W.Bode |
581 |
Acta
Crystallogr., Sect.D |
56 |
2000 |
| B |
59 |
| 1EJM
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF THE BPTI ALA16LEU MUTANT IN COMPLEX WITH BOVINE TRYPSIN |
A |
223 |
7.500 |
0.211 |
1.850 |
A.Grzesiak,
R.Helland, A.Smalas, D.Krowarsch, M.Dadlez, J.Otlewski |
205 |
J.Mol.Biol. |
301 |
2000 |
| B |
58 |
| C |
223 |
| D |
58 |
| E |
223 |
| F |
58 |
| 1ETR
|
X-RAY
DIFFRACTION |
REFINED
2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES
FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS
/NAPAP, 4-/TAPAP AND /MQPA: A STARTING POINT FOR IMPROVING
ANTITHROMBOTICS |
H |
259 |
n/a |
0.175 |
2.200 |
H.Brandstetter,
D.Turk, H.W.Hoeffken, D.Grosse, J.Sturzebecher, P.D.Martin,
B.F.Edwards, W.Bode |
1085 |
J
Mol Biol |
226 |
1992 |
| L |
49 |
| M |
3 |
| 1ETS
|
X-RAY
DIFFRACTION |
REFINED
2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES
FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS
/NAPAP, 4-/TAPAP AND /MQPA: A STARTING POINT FOR IMPROVING
ANTITHROMBOTICS |
H |
259 |
n/a |
0.178 |
2.300 |
H.Brandstetter,
D.Turk, H.W.Hoeffken, D.Grosse, J.Sturzebecher, P.D.Martin,
B.F.Edwards, W.Bode |
1085 |
J
Mol Biol |
226 |
1992 |
| L |
49 |
| N |
4 |
| 1ETT
|
X-RAY
DIFFRACTION |
REFINED
2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES
FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS
/NAPAP, 4-/TAPAP AND /MQPA: A STARTING POINT FOR IMPROVING
ANTITHROMBOTICS |
H |
259 |
n/a |
0.167 |
2.500 |
H.Brandstetter,
D.Turk, H.W.Hoeffken, D.Grosse, J.Sturzebecher, P.D.Martin,
B.F.Edwards, W.Bode |
1085 |
J
Mol Biol |
226 |
1992 |
| L |
49 |
| T |
3 |
| 1EUF
|
X-RAY
DIFFRACTION |
BOVINE
DUODENASE(NEW SERINE PROTEASE), CRYSTAL STRUCTURE |
A |
227 |
6.700 |
0.179 |
2.400 |
V.Z.Pletnev,
T.S.Zamolodchikova, W.A.Pangborn, W.L.Duax |
8 |
Proteins:
Struct., Funct., Genet. |
41 |
2000 |
| 1EZQ
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515 |
A |
254 |
5.700 |
0.208 |
2.200 |
S.Maignan,
J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein,
W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol |
3226 |
J.Med.Chem. |
43 |
2000 |
| B |
134 |
| 1EZX
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF A SERPIN:PROTEASE COMPLEX |
A |
335 |
8.000 |
0.205 |
2.600 |
J.A.Huntington,
R.J.Read, R.W.Carrell |
923 |
Nature |
407 |
2000 |
| B |
36 |
| C |
243 |
| 1F0R
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815 |
A |
254 |
5.700 |
0.216 |
2.100 |
S.Maignan,
J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein,
W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol |
3226 |
J.Med.Chem. |
43 |
2000 |
| B |
134 |
| 1F0S
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208707 |
A |
254 |
5.700 |
0.216 |
2.100 |
S.Maignan,
J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein,
W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol |
3226 |
J.Med.Chem. |
43 |
2000 |
| B |
134 |
| 1F0T
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN COMPLEXED WITH RPR131247 |
A |
243 |
6.000 |
0.179 |
1.800 |
S.Maignan,
J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein,
W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol |
3226 |
J.Med.Chem. |
43 |
2000 |
| 1F0U
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN COMPLEXED WITH RPR128515 |
A |
243 |
6.000 |
0.172 |
1.900 |
S.Maignan,
J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein,
W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol |
3226 |
J.Med.Chem. |
43 |
2000 |
| 1F2S
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A,
A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION |
E |
223 |
5.100 |
0.177 |
1.790 |
Y.Zhu,
Q.Huang, M.Qian, Y.Jia, Y.Tang |
505 |
J.Protein
Chem. |
18 |
1999 |
| I |
28 |
| 1F5R
|
X-RAY
DIFFRACTION |
RAT
TRYPSINOGEN MUTANT COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR |
A |
231 |
6.500 |
0.189 |
1.650 |
A.Pasternak,
A.White, C.J.Jeffery, N.Medina, M.Cahoon, D.Ringe, L.Hedstrom |
1331 |
Protein
Sci. |
10 |
2001 |
| I |
65 |
| 1F7Z
|
X-RAY
DIFFRACTION |
RAT
TRYPSINOGEN K15A COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR |
A |
233 |
n/a |
0.199 |
1.550 |
A.Pasternak,
A.White, C.J.Jeffery, N.Medina, M.Cahoon, D.Ringe, L.Hedstrom |
1331 |
Protein
Sci. |
10 |
2001 |
| I |
65 |
| 1FJS
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA |
A |
234 |
8.000 |
0.196 |
1.920 |
M.Adler,
D.D.Davey, G.B.Phillips, S.H.Kim, J.Jancarik, G.Rumennik, D.L.Light,
M.Whitlow |
12534 |
Biochemistry |
39 |
2000 |
| L |
52 |
| 1FY8
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF THE DELTAILE16VAL17 RAT ANIONIC TRYPSINOGEN-BPTI COMPLEX |
E |
231 |
8.500 |
0.183 |
1.700 |
A.Pasternak,
A.White, C.J.Jeffery, N.Medina, M.Cahoon, D.Ringe, L.Hedstrom |
1331 |
Protein
Sci. |
10 |
2001 |
| I |
58 |
| 1G36
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR COMPLEX |
A |
223 |
n/a |
0.174 |
1.900 |
H.Nar,
M.Bauer, A.Schmid, J.Stassen, W.Wienen, H.W.Priepke, I.K.Kauffmann,
U.J.Ries, N.H.Hauel |
29 |
Structure |
9 |
2001 |
| 1G3B
|
X-RAY
DIFFRACTION |
BOVINE
BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE MAGNESIUM(II) CHELATE |
A |
228 |
8.300 |
0.173 |
1.800 |
E.Toyota,
K.K.S.Ng, H.Sekizaki, K.Itoh, K.Tanizawa, M.N.G.James |
471 |
J.Mol.Biol. |
305 |
2000 |
| 1G3C
|
X-RAY
DIFFRACTION |
BOVINE
BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF BASE IRON(III) CHELATE |
A |
228 |
8.300 |
0.172 |
1.800 |
E.Toyota,
K.K.S.Ng, H.Sekizaki, K.Itoh, K.Tanizawa, M.N.G.James |
471 |
J.Mol.Biol. |
305 |
2000 |
| 1G3D
|
X-RAY
DIFFRACTION |
BOVINE
BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE COPPER (II) CHELATE |
A |
228 |
8.300 |
0.170 |
1.800 |
E.Toyota,
K.K.S.Ng, H.Sekizaki, K.Itoh, K.Tanizawa, M.N.G.James |
471 |
J.Mol.Biol. |
305 |
2000 |
| 1G3E
|
X-RAY
DIFFRACTION |
BOVINE
BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF-BASE COPPER (II) CHELATE |
A |
228 |
8.300 |
0.170 |
1.800 |
E.Toyota,
K.K.S.Ng, H.Sekizaki, K.Itoh, K.Tanizawa, M.N.G.James |
471 |
J.Mol.Biol. |
305 |
2000 |
| 1G9I
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF BETA-TRYSIN COMPLEX IN CYCLOHEXANE |
E |
223 |
6.400 |
0.185 |
2.200 |
G.Zhu,
Q.Huang, Y.Zhu, Y.Li, C.Chi, Y.Tang |
98 |
Biochim.Biophys.Acta |
1546 |
2001 |
| I |
22 |
| 1GHZ
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.175 |
1.390 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI0
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.179 |
1.420 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI1
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.167 |
1.420 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI2
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.184 |
1.380 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI3
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.202 |
1.440 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI4
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.193 |
1.370 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI5
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.200 |
1.600 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GI6
|
X-RAY
DIFFRACTION |
A
NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT
HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
A |
223 |
8.100 |
0.186 |
1.490 |
B.A.Katz,
K.Elrod, C.Luong, M.Rice, R.L.Mackman, P.A.Sprengeler, J.Spencer,
J.Hatayte, J.Janc, J.Link, J.Litvak, R.Rai, K.Rice, S.Sideris,
E.Verner, W.Young |
1451 |
J.Mol.Biol. |
307 |
2001 |
| 1GJ6
|
X-RAY
DIFFRACTION |
ENGINEERING
INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE
SERINE PROTEASE DRUG TARGETS |
A |
223 |
8.100 |
0.187 |
1.500 |
B.A.Katz,
P.A.Sprengeler, C.Luong, E.Verner, K.Elrod, M.Kirtley, J.Janc,
J.R.Spencer, J.G.Breitenbucher, H.Hui, D.Mcgee, D.Allen, A.Martelli,
R.L.Mackman |
1107 |
Chem.Biol. |
8 |
2002 |
| 1GL0
|
X-RAY
DIFFRACTION |
STRUCTURE
OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-D2V, AN
INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA |
E |
245 |
5.000 |
0.174 |
3.000 |
A.Roussel,
M.Mathieu, A.Dobbs, B.Luu, C.Cambillau, C.Kellenberger |
38893 |
J.Biol.Chem. |
276 |
2001 |
| I |
35 |
| 1GL1
|
X-RAY
DIFFRACTION |
STRUCTURE
OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-C, AN
INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA |
A |
245 |
5.000 |
0.189 |
2.100 |
A.Roussel,
M.Mathieu, A.Dobbs, B.Luu, C.Cambillau, C.Kellenberger |
38893 |
J.Biol.Chem. |
276 |
2001 |
| B |
245 |
| C |
245 |
| I |
36 |
| J |
36 |
| K |
36 |
| 1H8D
|
X-RAY
DIFFRACTION |
X-RAY
STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE
PHOSPHONATE INHIBITOR. |
H |
260 |
7.200 |
0.170 |
1.400 |
E.Skordalakes,
G.G.Dodson, D.S.Green, C.A.Goodwin, M.F.Scully, H.R.Hudson, V.V.Kakkar,
J.J.Deadman |
549 |
J.Mol.Biol. |
311 |
2001 |
| I |
10 |
| L |
29 |
| 1H8I
|
X-RAY
DIFFRACTION |
X-RAY
CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN WITH A TRIPEPTIDE PHOSPHONATE
INHIBITOR. |
H |
253 |
7.200 |
0.186 |
1.750 |
E.Skordalakes,
G.G.Dodson, D.S.Green, C.A.Goodwin, M.F.Scully, H.R.Hudson, V.V.Kakkar,
J.J.Deadman |
549 |
J.Mol.Biol. |
311 |
2001 |
| I |
10 |
| L |
27 |
| 1HJ8
|
X-RAY
DIFFRACTION |
1.00
AA TRYPSIN FROM ATLANTIC SALMON |
A |
222 |
5.800 |
0.118 |
1.000 |
H.-K.S.Leiros,
S.M.Mcsweeney, A.O.Smalas |
488 |
Acta
Crystallogr.,Sect.D |
57 |
2001 |
| 1HJ9
|
X-RAY
DIFFRACTION |
ATOMIC
RESOLUTION STRUCTURES OF TRYPSIN PROVIDE INSIGHT INTO STRUCTURAL
RADIATION DAMAGE |
A |
223 |
8.000 |
0.117 |
0.950 |
H.-K.S.Leiros,
S.M.Mcsweeney, A.O.Smalas |
488 |
Acta
Crystallogr.,Sect.D |
57 |
2001 |
| 1ID5
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF BOVINE THROMBIN COMPLEX WITH PROTEASE INHIBITOR ECOTIN |
H |
256 |
5.000 |
0.203 |
2.500 |
S.X.Wang,
C.T.Esmon, R.J.Fletterick |
10038 |
Biochemistry |
40 |
2001 |
| I |
142 |
| L |
49 |
| 1J8A
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF BENZAMIDINE INHIBITED BOVINE PANCREATIC TRYPSIN AT 105K TO
1.21A RESOLUTION FROM LABORATORY SOURCE WITH HIGH NUMBER OF WATERS
MODELLED |
A |
223 |
7.400 |
0.160 |
1.210 |
J.A.Cuesta-Seijo,
S.Garcia-Granda |
n/a |
To
be Published |
n/a |
n/a |
| 1JIR
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF TRYPSIN COMPLEX WITH AMYLAMINE IN CYCLOHEXANE |
A |
223 |
6.000 |
0.169 |
2.000 |
G.Wu,
G.Zhu, Q.Huang, M.Qian, Y.Tang |
n/a |
To
be Published |
n/a |
n/a |
| 1JRS
|
X-RAY
DIFFRACTION |
HEMIACETAL
COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN |
A |
223 |
n/a |
0.175 |
1.800 |
I.V.Kurinov,
R.W.Harrison |
752 |
Protein
Sci |
5 |
1996 |
| B |
4 |
| 1JRT
|
X-RAY
DIFFRACTION |
HEMIACETAL
COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN |
A |
223 |
n/a |
0.177 |
1.800 |
I.V.Kurinov,
R.W.Harrison |
752 |
Protein
Sci |
5 |
1996 |
| B |
4 |
| 1K1I
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
7.000 |
0.165 |
2.200 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K1J
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
n/a |
0.168 |
2.200 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K1L
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
n/a |
0.167 |
2.500 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K1M
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
n/a |
0.163 |
2.200 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K1N
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
n/a |
0.168 |
2.000 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K1O
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
n/a |
0.165 |
2.000 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K1P
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN-INHIBITOR COMPLEX |
A |
223 |
n/a |
0.170 |
1.900 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| 1K21
|
X-RAY
DIFFRACTION |
HUMAN
THROMBIN-INHIBITOR COMPLEX |
H |
259 |
n/a |
0.216 |
1.860 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| I |
12 |
| L |
36 |
| 1K22
|
X-RAY
DIFFRACTION |
HUMAN
THROMBIN-INHIBITOR COMPLEX |
H |
259 |
n/a |
0.197 |
1.930 |
F.Dullweber,
M.T.Stubbs, D.Musil, J.Sturzebecher, G.Klebe |
593 |
J.Mol.Biol. |
313 |
2001 |
| I |
12 |
| L |
36 |
| 1KIG
|
X-RAY
DIFFRACTION |
BOVINE
FACTOR XA |
H |
241 |
n/a |
0.187 |
3.000 |
A.Wei,
R.S.Alexander, J.Duke, H.Ross, S.A.Rosenfeld, C.H.Chang |
147 |
J
Mol Biol |
283 |
1998 |
| I |
60 |
| L |
51 |
| 1KSN
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH FXV673 |
A |
254 |
5.700 |
0.223 |
2.100 |
K.R.Guertin,
C.J.Gardner, S.I.Klein, A.L.Zulli, M.Czekaj, Y.Gong, A.P.Spada,
D.L.Cheney, S.Maignan, J.-P.Guilloteau, K.D.Brown, D.C.Colussi, V.Chu,
C.L.Heran, S.R.Morgan, R.G.Bentley, C.T.Dunwiddie, R.J.Leadley,
H.W.Pauls |
1671 |
Bioorg.Med.Chem.Lett. |
12 |
2002 |
| B |
134 |
| 1LCN
|
X-RAY
DIFFRACTION |
MONOCLINIC
HEN EGG WHITE LYSOZYME, THIOCYANATE COMPLEX |
A |
129 |
5.000 |
0.198 |
1.630 |
C.Hamiaux,
S.Lafont, M.Ries-Kautt, M.C.Vaney, A.Ducruix, T.Prange |
n/a |
To
be Published |
n/a |
n/a |
| B |
129 |
| 1LQE
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF TRYPSIN IN COMPLEX WITH 79. |
A |
243 |
6.000 |
0.166 |
2.200 |
H.Matter,
E.Defossa, U.Heinelt, P.M.Blohm, D.Schneider, A.Mueller, S.Herok,
H.A.Schreuder, A.Liesum, V.Brachvogel, P.Loenze, A.Walser, F.Al-Obeidi,
P.Wildgoose |
2749 |
J.Med.Chem. |
45 |
2002 |
| 1MAX
|
X-RAY
DIFFRACTION |
BETA-TRYPSIN
PHOSPHONATE INHIBITED |
n/a |
223 |
n/a |
0.211 |
1.800 |
J.A.Bertrand,
J.Oleksyszyn, C.M.Kam, B.Boduszek, S.Presnell, R.R.Plaskon,
F.L.Suddath, J.C.Powers, L.D.Williams |
3147 |
Biochemistry |
35 |
1996 |
| 1MAY
|
X-RAY
DIFFRACTION |
BETA-TRYPSIN
PHOSPHONATE INHIBITED |
n/a |
223 |
n/a |
0.178 |
1.800 |
J.A.Bertrand,
J.Oleksyszyn, C.M.Kam, B.Boduszek, S.Presnell, R.R.Plaskon,
F.L.Suddath, J.C.Powers, L.D.Williams |
3147 |
Biochemistry |
35 |
1996 |
| 1MBQ
|
X-RAY
DIFFRACTION |
ANIONIC
TRYPSIN FROM PACIFIC CHUM SALMON |
A |
220 |
8.150 |
0.166 |
1.800 |
E.Toyota,
K.K.S.Ng, S.Kuninaga, H.Sekizaki, K.Itoh, K.Tanizawa, M.N.G.James |
391 |
J.Mol.Biol. |
324 |
2002 |
| 1MCT
|
X-RAY
DIFFRACTION |
THE
REFINED 1.6 ANGSTROMS RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX
FORMED BETWEEN PORCINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF
SQUASH FAMILY |
A |
223 |
n/a |
0.167 |
1.600 |
Q.Huang,
S.Liu, Y.Tang |
1022 |
J
Mol Biol |
229 |
1993 |
| I |
28 |
| 1MCV
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE ANALYSIS OF A HYBRID SQUASH INHIBITOR IN COMPLEX WITH PORCINE
PANCREATIC ELASTASE |
A |
240 |
6.000 |
0.182 |
1.800 |
J.Ay,
K.Hilpert, N.Krauss, J.Schneider-Mergener, W.Hoehne |
247 |
Acta
Crystallogr., Sect.D |
59 |
2003 |
| I |
28 |
| 1MTN
|
X-RAY
DIFFRACTION |
BOVINE
ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION |
A |
13 |
6.000 |
0.180 |
2.800 |
C.Capasso,
M.Rizzi, E.Menegatti, P.Ascenzi, M.Bolognesi |
26 |
J
Mol Recognit |
10 |
1997 |
| B |
131 |
| C |
97 |
| D |
58 |
| E |
13 |
| F |
131 |
| G |
97 |
| H |
58 |
| 1MTS
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN |
n/a |
223 |
6.000 |
0.179 |
1.900 |
M.T.Stubbs,
R.Huber, W.Bode |
103 |
FEBS
Lett |
375 |
1995 |
| 1MTU
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN |
n/a |
223 |
6.000 |
0.179 |
1.900 |
M.T.Stubbs,
R.Huber, W.Bode |
103 |
FEBS
Lett |
375 |
1995 |
| 1MTV
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN |
n/a |
223 |
7.000 |
0.169 |
1.900 |
M.T.Stubbs,
R.Huber, W.Bode |
103 |
FEBS
Lett |
375 |
1995 |
| 1MTW
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN |
n/a |
223 |
8.000 |
0.169 |
1.900 |
M.T.Stubbs,
R.Huber, W.Bode |
103 |
FEBS
Lett |
375 |
1995 |
| 1N6X
|
X-RAY
DIFFRACTION |
RIP-PHASING
ON BOVINE TRYPSIN |
A |
223 |
8.000 |
0.139 |
1.400 |
R.B.G.Ravelli,
H.K.Schroder Leiros, B.Pan, M.Caffrey, S.Mcsweeney |
217 |
Structure |
11 |
2003 |
| 1N6Y
|
X-RAY
DIFFRACTION |
RIP-PHASING
ON BOVINE TRYPSIN |
A |
223 |
8.000 |
0.142 |
1.400 |
R.B.G.Ravelli,
H.K.Schroder Leiros, B.Pan, M.Caffrey, S.Mcsweeney |
217 |
Structure |
11 |
2003 |
| 1NAG
|
X-RAY
DIFFRACTION |
CREVICE-FORMING
MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR:
CRYSTAL STRUCTURES OF /F22A, /Y23A, /N43G, AND /F45A |
n/a |
58 |
n/a |
0.163 |
1.850 |
A.T.Danishefsky,
D.Housset, K.S.Kim, F.Tao, J.Fuchs, C.Woodward, A.Wlodawer |
577 |
Protein
Sci |
2 |
1993 |
| 1NC6
|
X-RAY
DIFFRACTION |
POTENT,
SMALL MOLECULE INHIBITORS OF HUMAN MAST CELL TRYPTASE. ANTI-ASTHMATIC
ACTION OF A DIPEPTIDE-BASED TRANSITION STATE ANALOGUE CONTAINING
BENZOTHIAZOLE KETONE |
A |
223 |
7.750 |
0.175 |
1.900 |
M.J.Costanzo,
S.C.Yabut, H.R.Almond Jr., P.Andrade-Gordon, T.W.Corcoran, L.De
Garavilla, J.A.Kauffman, W.M.Abraham, R.Recacha, D.Chattopadhyay,
B.E.Maryanoff |
3865 |
J.Med.Chem. |
46 |
2003 |
| 1NTP
|
NEUTRON
DIFFRACTION |
USE
OF THE NEUTRON DIFFRACTION-H(SLASH)D EXCHANGE TECHNIQUE TO DETERMINE
THE CONFORMATIONAL DYNAMICS OF TRYPSIN |
n/a |
223 |
n/a |
0.187 |
1.800 |
A.A.Kossiakoff |
281 |
Basic
Life Sci. |
27 |
1984 |
| 1O2H
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.192 |
1.770 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2I
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.190 |
1.500 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2J
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.177 |
1.650 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2K
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.180 |
1.630 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2L
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.191 |
1.680 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2M
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.195 |
1.690 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2N
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.192 |
1.500 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2O
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.186 |
1.630 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2P
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.194 |
1.470 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.-F.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2Q
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.177 |
1.500 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2R
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.198 |
1.450 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2S
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.183 |
1.650 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2T
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.179 |
1.620 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2U
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.196 |
1.410 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2V
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.211 |
1.500 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2W
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.203 |
1.380 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2X
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.217 |
1.460 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2Y
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.204 |
1.450 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O2Z
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.188 |
1.650 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O30
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.180 |
1.550 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O31
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.188 |
1.660 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O32
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.190 |
1.780 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O33
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.179 |
1.460 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O34
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.181 |
1.500 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O35
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.164 |
1.410 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O36
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.188 |
1.700 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O37
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.225 |
1.450 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O38
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.190 |
1.380 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O39
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.183 |
1.590 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3A
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.186 |
2.000 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3B
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.167 |
1.750 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3C
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.180 |
1.640 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3D
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.194 |
1.330 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3E
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.170 |
1.640 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3F
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.187 |
1.550 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3G
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.181 |
1.550 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3H
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.179 |
1.530 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3I
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.188 |
1.510 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3J
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.188 |
1.400 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3K
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.180 |
1.430 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3L
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.208 |
1.400 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3M
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.173 |
1.550 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3N
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.170 |
1.550 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1O3O
|
X-RAY
DIFFRACTION |
ELABORATE
MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE
SITE-DIRECTED SERINE PROTEASE INHIBITORS |
A |
223 |
8.100 |
0.190 |
1.550 |
B.A.Katz,
K.Elrod, E.Verner, R.L.Mackman, C.Luong, W.D.Shrader, M.Sendzik,
J.R.Spencer, P.A.Sprengeler, A.Kolesnikov, V.W.Tai, H.C.Hui,
J.G.Breitenbucher, D.Allen, J.W.Janc |
93 |
J.Mol.Biol. |
329 |
2003 |
| 1OPH
|
X-RAY
DIFFRACTION |
NON-COVALENT
COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN |
A |
394 |
8.300 |
0.190 |
2.300 |
A.Dementiev,
M.Simonovic, K.Volz, P.G.Gettins |
37881 |
J.Biol.Chem. |
278 |
2003 |
| B |
243 |
| 1OYQ
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR COMPLEX |
A |
223 |
n/a |
0.176 |
1.900 |
H.Nar,
M.Bauer, A.Schmid, J.Stassen, W.Wienen, H.W.Priepke, I.K.Kauffmann,
U.J.Ries, N.H.Hauel |
29 |
Structure |
9 |
2001 |
| 1P2I
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
223 |
7.500 |
0.201 |
1.650 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| I |
58 |
| 1P2J
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
223 |
7.500 |
0.164 |
1.350 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| I |
58 |
| 1P2K
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
223 |
7.500 |
0.200 |
1.600 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| I |
58 |
| 1P2M
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
245 |
7.800 |
0.206 |
1.750 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| B |
58 |
| C |
245 |
| D |
58 |
| 1P2N
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
245 |
7.800 |
0.199 |
1.800 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| B |
58 |
| C |
245 |
| D |
58 |
| 1P2O
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
245 |
7.800 |
0.227 |
2.000 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| B |
58 |
| C |
245 |
| D |
58 |
| 1P2Q
|
X-RAY
DIFFRACTION |
STRUCTURAL
CONSEQUENCES OF ACCOMMODATION OF FOUR NON-COGNATE AMINO-ACID RESIDUES
IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN |
A |
245 |
7.800 |
0.206 |
1.800 |
R.Helland,
H.Czapinska, I.Leiros, M.Olufsen, J.Otlewski, A.O.Smalaas |
845 |
J.Mol.Biol. |
333 |
2003 |
| B |
58 |
| C |
245 |
| D |
58 |
| 1PPC
|
X-RAY
DIFFRACTION |
GEOMETRY
OF BINDING OF THE BENZAMIDINE-AND ARGININE-BASED INHIBITORS
N==ALPHA==-(2-NAPHTHYL-SULPHONYL-GLYCYL)-DL-P-AMIDINOPHENYLALANYL-PIPERIDINE
(NAPAP) AND (2R,4R)-4-METHYL-1-[N==ALPHA==-(3-METHYL-1,2,3,4-TETRAHYDRO
8-QUINOLINESULPHONYL)-L-ARGINYL]-2-PI |
E |
223 |
n/a |
0.181 |
1.800 |
W.Bode,
D.Turk, J.Sturzebecher |
175 |
Eur
J Biochem |
193 |
1990 |
| I |
4 |
| 1PPE
|
X-RAY
DIFFRACTION |
THE
REFINED 2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED
BETWEEN BOVINE BETA-TRYPSIN AND CMTI-I, A TRYPSIN INHIBITOR FROM SQUASH
SEEDS (CUCURBITA MAXIMA): TOPOLOGICAL SIMILARITY OF THE SQUASH SEED
INHIBITORS WITH THE CARBOXYPEPTIDASE A INHI |
E |
223 |
n/a |
0.151 |
2.000 |
W.Bode,
H.J.Greyling, R.Huber, J.Otlewski, T.Wilusz |
285 |
FEBS
Lett |
242 |
1989 |
| I |
29 |
| 1PPH
|
X-RAY
DIFFRACTION |
GEOMETRY
OF BINDING OF THE NALPHA-TOSYLATED PIPERIDIDES OF M-AMIDINO-,
P-AMIDINO-AND P-GUANIDINO PHENYLALANINE TO THROMBIN AND TRYPSIN: X-RAY
CRYSTAL STRUCTURES OF THEIR TRYPSIN COMPLEXES AND MODELING OF THEIR
THROMBIN COMPLEXES |
E |
223 |
n/a |
0.167 |
1.900 |
D.Turk,
J.Sturzebecher, W.Bode |
133 |
FEBS
Lett |
287 |
1991 |
| I |
3 |
| 1QA0
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN 2-AMINOBENZIMIDAZOLE COMPLEX |
A |
223 |
7.400 |
0.172 |
1.800 |
M.Whitlow,
D.O.Arnaiz, B.O.Buckman, D.D.Davey, B.Griedel, W.J.Guilford,
S.K.Koovakkat, A.Liang, R.Mohan, G.B.Phillips, M.Seto, K.J.Shaw, W.Xu,
Z.Zhao, D.R.Light, M.M.Morrissey |
1395 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| 1QB1
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN WITH 1-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-6-[3-(4,5-
DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL
PHENOXY]PYRIDIN-4-YL]PIPERIDINE-3-CARBOXYLIC ACID (ZK-806974) |
A |
223 |
7.400 |
0.183 |
1.800 |
M.Whitlow,
D.O Arnaiz, B.O.Buckman, D.D.Davey, B.Griedel, W.J.Guilford,
S.K.Koovakkat, A.Liang, R.Mohan, G.B.Phillips, M.Seto, K.J.Shaw, W.Xu,
Z.Zhao, D.R.Light, M.M.Morrissey |
1395 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| 1QB6
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN 3,3'-[3,5-DIFLUORO-4-METHYL-2, 6-PYRIDINEDIYLBIS(OXY)]BIS(
BENZENECARBOXIMIDAMIDE) (ZK-805623 COMPLEX |
A |
223 |
7.400 |
0.188 |
1.800 |
M.Whitlow,
D.O.Arnaiz, B.O.Buckman, D.D.Davey, B.Griedel, W.J.Guilford,
S.K.Koovakkat, A.Liang, R.Mohan, G.B.Phillips, M.Seto, K.J.Shaw, W.Xu,
Z.Zhao, D.R.Light, M.M.Morrissey |
1395 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| 1QB9
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL]
METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX |
A |
223 |
7.400 |
0.176 |
1.800 |
M.Whitlow,
D.O.Arnaiz, B.O.Buckman, D.D.Davey, B.Griedel, W.J.Guilford,
S.K.Koovakkat, A.Liang, R.Mohan, G.B.Phillips, M.Seto, K.J.Shaw, W.Xu,
Z.Zhao, D.R.Light, M.M.Morrissey |
1395 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| 1QBN
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN 2-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-6-[3-(4,5-DIHYDRO-1H-
IMIDAZOL-2-YL)PHENOXY]PYRIDINE-4-CARBOXYLIC ACID (ZK-806688) COMPLEX |
A |
223 |
7.400 |
0.155 |
1.800 |
M.Whitlow,
D.O Arnaiz, B.O.Buckman, D.D.Davey, B.Griedel, W.J.Guilford,
S.K.Koovakkat, A.Liang, R.Mohan, G.B.Phillips, M.Seto, K.J.Shaw, W.Xu,
Z.Zhao, D.R.Light, M.M.Morrissey |
1395 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| 1QBO
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN 7-[[6-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-2-METHYL-
BENZIMIDAZOL-1-YL]METHYL]NAPHTHALENE-2-CARBOXIMIDAMID ZK-806711
INHIBITOR COMPLEX |
A |
223 |
7.400 |
0.187 |
1.800 |
M.Whitlow,
D.O.Arnaiz, B.O.Buckman, D.D.Davey, B.Griedel, W.J.Guilford,
S.K.Koovakkat, A.Liang, R.Mohan, G.B.Phillips, M.Seto, K.J.Shaw, W.Xu,
Z.Zhao, D.R.Light, M.M.Morrissey |
1395 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| 1QL7
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN |
A |
223 |
8.000 |
0.200 |
2.100 |
M.T.Stubbs,
S.Reyda, F.Dullweber, M.Moeller, G.Klebe, K.D.Ullmann, H.D.Jakubke,
D.Dorsch, W.W.K.R.Mederski, H.Wurzig |
n/a |
To
be Published |
n/a |
n/a |
| 1QL8
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN |
A |
223 |
7.000 |
0.190 |
3.000 |
M.T.Stubbs,
S.Reyda, F.Dullweber, M.Moeller, G.Klebe, K.D.Ullmann, H.D.Jakubke,
D.Dorsch, W.W.K.R.Mederski, H.Wurzig |
n/a |
To
be Published |
n/a |
n/a |
| 1QL9
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH RAT TRYPSIN MUTANT X99RT |
A |
223 |
7.000 |
0.189 |
2.300 |
M.T.Stubbs,
S.Reyda, F.Dullweber, M.Moeller, G.Klebe, K.D.Ullmann, H.D.Jakubke,
D.Dorsch, W.W.K.R.Mederski, H.Wurziger |
n/a |
To
be Published |
n/a |
n/a |
| 1RXP
|
X-RAY
DIFFRACTION |
STRUCTURE
OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL-
PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC
ACID |
A |
223 |
n/a |
0.195 |
1.700 |
J.C.Sutton,
S.A.Bolton, M.E.Davis, K.S.Hartl, B.Jacobson, A.Mathur, M.L.Ogletree,
W.A.Slusarchyk, R.Zahler, S.M.Seiler, G.S.Bisacchi |
2233 |
Bioorg.Med.Chem.Lett. |
14 |
2004 |
| 1SFI
|
X-RAY
DIFFRACTION |
HIGH
RESOLUTION STRUCTURE OF A POTENT, CYCLIC PROTEASE INHIBITOR FROM
SUNFLOWER SEEDS |
A |
223 |
8.000 |
0.175 |
1.650 |
S.Luckett,
R.S.Garcia, J.J.Barker, A.V.Konarev, P.Shewry, A.R.Clarke, R.L.Brady |
525 |
J.Mol.Biol. |
290 |
1999 |
| I |
14 |
| 1TAW
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN COMPLEXED TO APPI |
A |
223 |
6.500 |
0.184 |
1.800 |
A.J.Scheidig,
T.R.Hynes, L.A.Pelletier, J.A.Wells, A.A.Kossiakoff |
1806 |
Protein
Sci |
6 |
1997 |
| B |
58 |
| 1TGB
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF BOVINE TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. II.
CRYSTALLOGRAPHIC REFINEMENT, REFINED CRYSTAL STRUCTURE AND COMPARISON
WITH BOVINE TRYPSIN |
n/a |
229 |
n/a |
n/a |
1.800 |
H.Fehlhammer,
W.Bode, R.Huber |
415 |
J
Mol Biol |
111 |
1977 |
| 1TGC
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
n/a |
229 |
n/a |
0.180 |
1.800 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| 1TGN
|
X-RAY
DIFFRACTION |
STRUCTURE
OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION |
n/a |
229 |
n/a |
0.223 |
1.650 |
A.A.Kossiakoff,
J.L.Chambers, L.M.Kay, R.M.Stroud |
654 |
Biochemistry |
16 |
1977 |
| 1TGT
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
n/a |
229 |
n/a |
0.187 |
1.700 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| 1TIO
|
X-RAY
DIFFRACTION |
HIGH
PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE |
A |
223 |
6.200 |
0.185 |
1.930 |
G.Zhu,
Q.Huang, Z.Wang, M.Qian, Y.Jia, Y.Tang |
142 |
Biochim
Biophys Acta |
1429 |
1998 |
| 1TLD
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF BOVINE BETA-TRYPSIN AT 1.5 ANGSTROMS RESOLUTION IN A
CRYSTAL FORM WITH LOW MOLECULAR PACKING DENSITY. ACTIVE SITE GEOMETRY,
ION PAIRS AND SOLVENT STRUCTURE |
n/a |
223 |
n/a |
0.167 |
1.500 |
H.D.Bartunik,
L.J.Summers, H.H.Bartsch |
813 |
J
Mol Biol |
210 |
1989 |
| 1TPA
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
E |
223 |
n/a |
0.175 |
1.900 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr B |
39 |
1983 |
| I |
58 |
| 1TPO
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
n/a |
223 |
n/a |
0.180 |
1.700 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr B |
39 |
1983 |
| 1TPP
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
n/a |
223 |
n/a |
0.191 |
1.400 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr B |
39 |
1983 |
| 1TRY
|
X-RAY
DIFFRACTION |
STRUCTURE
OF INHIBITED TRYPSIN FROM FUSARIUM OXYSPORUM AT 1.55 ANGSTROMS |
n/a |
224 |
n/a |
0.144 |
1.550 |
W.R.Rypniewski,
C.Dambmann, C.Vonderosten, M.Dauter, K.S.Wilson |
73 |
Acta
Crystallogr D Biol Crystallogr |
51 |
1995 |
| 1UTJ
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
242 |
6.000 |
0.162 |
1.830 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTK
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
242 |
6.000 |
0.177 |
1.530 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTL
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
M |
242 |
6.000 |
0.176 |
1.700 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTM
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
242 |
6.000 |
0.189 |
1.500 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTN
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
243 |
8.000 |
0.113 |
1.150 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTO
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
243 |
8.000 |
0.139 |
1.150 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTP
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
243 |
8.000 |
0.141 |
1.300 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1UTQ
|
X-RAY
DIFFRACTION |
TRYPSIN
SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND
ASSOCIATION CONSTANT MEASUREMENTS |
A |
243 |
8.000 |
0.138 |
1.150 |
H.-K.S.Leiros,
B.O.Brandsdal, O.A.Andersen, V.Os, I.Leiros, R.Helland, J.Otlewski,
N.P.Willassen, A.O.Smalas |
1056 |
Protein
Sci. |
13 |
2004 |
| 1V2J
|
X-RAY
DIFFRACTION |
BENZAMIDINE
IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSRI) BT.C1 |
T |
223 |
6.000 |
0.216 |
1.900 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2K
|
X-RAY
DIFFRACTION |
FACTOR
XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT
X(TRIPLE.GLU)BT.D2 |
T |
223 |
6.000 |
0.192 |
2.000 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2L
|
X-RAY
DIFFRACTION |
BENZAMIDINE
IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(TRIPLE.GLU)BT.D1 |
T |
223 |
6.000 |
0.189 |
1.600 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2M
|
X-RAY
DIFFRACTION |
BENZAMIDINE
IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(TRIPLE.GLU)BT.A1 |
T |
223 |
8.000 |
0.213 |
1.650 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2N
|
X-RAY
DIFFRACTION |
POTENT
FACTOR XA INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT
X(99/175/190)BT |
T |
223 |
7.000 |
0.173 |
1.800 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2O
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSYI)BT.B4 |
T |
223 |
8.000 |
0.183 |
1.620 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2P
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSYI)BT.A4 |
T |
223 |
8.000 |
0.213 |
1.920 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2Q
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSWI)BT.B4 |
T |
223 |
7.000 |
0.186 |
2.300 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2R
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSRI)BT.B4 |
T |
223 |
7.000 |
0.199 |
1.700 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2S
|
X-RAY
DIFFRACTION |
BENZAMIDINE
IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSFI.GLU)BT.D1 |
T |
223 |
6.000 |
0.197 |
1.720 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2T
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSFI.GLU)BT.B4 |
T |
223 |
7.000 |
0.211 |
1.900 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2U
|
X-RAY
DIFFRACTION |
BENZAMIDINE
IN COMPLEX WITH BOVINE TRYPSIN VARINAT X(SSAI) BT.D1 |
T |
223 |
6.000 |
0.190 |
1.800 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2V
|
X-RAY
DIFFRACTION |
BENZAMIDINE
IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSAI) BT.C1 |
T |
223 |
6.000 |
0.222 |
1.800 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1V2W
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSAI)BT.B4 |
T |
223 |
7.000 |
0.203 |
1.750 |
D.Rauh,
G.Klebe, M.T.Stubbs |
1325 |
J.Mol.Biol. |
335 |
2004 |
| 1XUF
|
X-RAY
DIFFRACTION |
TRYPSIN-BABIM-ZN+2,
PH 8.2 |
n/a |
223 |
8.200 |
0.153 |
2.040 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1XUG
|
X-RAY
DIFFRACTION |
TRYPSIN-BABIM-ZN+2,
PH 8.2 |
n/a |
223 |
8.200 |
0.206 |
1.500 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1XUH
|
X-RAY
DIFFRACTION |
TRYPSIN-KETO-BABIM-CO+2,
PH 8.2 |
n/a |
223 |
8.200 |
0.135 |
2.370 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1XUI
|
X-RAY
DIFFRACTION |
TRYPSIN-KETO-BABIM,
ZN+2-FREE, PH 8.2 |
n/a |
223 |
8.200 |
0.192 |
1.500 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1XUJ
|
X-RAY
DIFFRACTION |
TRYPSIN-KETO-BABIM-ZN+2,
PH 8.2 |
n/a |
223 |
8.200 |
0.144 |
1.920 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1XUK
|
X-RAY
DIFFRACTION |
TRYPSIN-BABIM-SULFATE,
PH 5.9 |
n/a |
223 |
8.200 |
0.130 |
2.040 |
B.A.Katz,
J.M.Clark, J.S.Finer-Moore, T.E.Jenkins, C.R.Johnson, M.J.Ross,
C.Luong, W.R.Moore, R.M.Stroud |
608 |
Nature |
391 |
1998 |
| 1YYY
|
X-RAY
DIFFRACTION |
TRYPSIN
INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES |
1 |
223 |
7.500 |
0.157 |
2.100 |
R.Krishnan,
E.Zhang, K.Hakansson, R.K.Arni, A.Tulinsky, M.S.Lim-Wilby, O.E.Levy,
J.E.Semple, T.K.Brunck |
12094 |
Biochemistry |
37 |
1998 |
| 2 |
4 |
| 2BTC
|
X-RAY
DIFFRACTION |
BOVINE
TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN
INHIBITOR II) |
E |
223 |
6.000 |
0.183 |
1.500 |
R.Helland,
G.I.Berglund, J.Otlewski, W.Apostoluk, O.A.Andersen, N.P.Willassen,
A.O.Smalas |
139 |
Acta
Crystallogr., Sect.D |
55 |
1999 |
| I |
29 |
| 2BZA
|
X-RAY
DIFFRACTION |
BOVINE
PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZYLAMINE |
A |
223 |
6.000 |
0.175 |
1.900 |
N.Ota,
C.Stroupe, J.M.S.Ferreira-Da-Silva, S.S.Shah, M.Mares-Guia, A.T.Brunger |
641 |
Proteins:
Struct., Funct., Genet. |
37 |
1999 |
| 2CGA
|
X-RAY
DIFFRACTION |
BOVINE
CHYMOTRYPSINOGEN A. X-RAY CRYSTAL STRUCTURE ANALYSIS AND REFINEMENT OF
A NEW CRYSTAL FORM AT 1.8 ANGSTROMS RESOLUTION |
A |
245 |
n/a |
0.170 |
1.800 |
D.Wang,
W.Bode, R.Huber |
595 |
J
Mol Biol |
185 |
1985 |
| B |
245 |
| 2KAI
|
X-RAY
DIFFRACTION |
REFINED
2.5 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY PORCINE
KALLIKREIN A AND THE BOVINE PANCREATIC TRYPSIN INHIBITOR.
CRYSTALLIZATION, PATTERSON SEARCH, STRUCTURE DETERMINATION, REFINEMENT,
STRUCTURE AND COMPARISON WITH ITS COMPONENTS A |
A |
80 |
n/a |
0.224 |
2.500 |
Z.Chen,
W.Bode |
283 |
J.Mol.Biol. |
164 |
1983 |
| B |
152 |
| I |
58 |
| 2PKA
|
X-RAY
DIFFRACTION |
REFINED
2 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF PORCINE PANCREATIC KALLIKREIN A,
A SPECIFIC TRYPSIN-LIKE SERINE PROTEINASE. CRYSTALLIZATION, STRUCTURE
DETERMINATION, CRYSTALLOGRAPHIC REFINEMENT, STRUCTURE AND ITS
COMPARISON WITH BOVINE TRYPSIN |
A |
80 |
n/a |
0.220 |
2.050 |
W.Bode,
Z.Chen, K.Bartels, C.Kutzbach, G.Schmidt-Kastner, H.Bartunik |
237 |
J.Mol.Biol. |
164 |
1983 |
| B |
152 |
| X |
80 |
| Y |
152 |
| 2PTC
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
E |
223 |
n/a |
0.187 |
1.900 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr.,Sect.B |
39 |
1983 |
| I |
58 |
| 2PTN
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
n/a |
223 |
n/a |
0.193 |
1.550 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| 2TBS
|
X-RAY
DIFFRACTION |
COLD-ADAPTION
OF ENZYMES: STRUCTURAL COMPARISON BETWEEN SALMON AND BOVINE TRYPSINS |
n/a |
222 |
n/a |
0.165 |
1.800 |
A.O.Smalas,
E.S.Heimstad, A.Hordvik, N.P.Willassen, R.Male |
149 |
Proteins |
20 |
1994 |
| 2TGA
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
n/a |
229 |
n/a |
0.197 |
1.800 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| 2TGD
|
X-RAY
DIFFRACTION |
LACK
OF THE TRANSITION STATE STABILIZATION SITE IS A FACTOR IN THE
INACTIVITY OF TRYPSINOGEN, A SERINE PROTEASE ZYMOGEN. STRUCTURE OF /DFP
INHIBITED BOVINE TRYPSINOGEN AT 2.1 ANGSTROMS RESOLUTION |
n/a |
229 |
n/a |
0.182 |
2.100 |
M.O.Jones,
R.M.Stroud |
n/a |
To
be Published |
n/a |
n/a |
| 2TGP
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
I |
58 |
n/a |
0.200 |
1.900 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr.,Sect.B |
39 |
1983 |
| Z |
229 |
| 2TGT
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
n/a |
229 |
n/a |
0.209 |
1.700 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| 2TIO
|
X-RAY
DIFFRACTION |
LOW
PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE |
A |
223 |
6.000 |
0.179 |
1.930 |
G.Zhu,
Q.Huang, Z.Wang, M.Qian, Y.Jia, Y.Tang |
142 |
Biochim
Biophys Acta |
1429 |
1998 |
| 2TLD
|
X-RAY
DIFFRACTION |
CRYSTAL
STRUCTURE OF AN ENGINEERED SUBTILISIN INHIBITOR COMPLEXED WITH BOVINE
TRYPSIN |
E |
220 |
n/a |
0.173 |
2.600 |
Y.Takeuchi,
T.Nonaka, K.T.Nakamura, S.Kojima, K.Miura, Y.Mitsui |
4407 |
Proc
Natl Acad Sci U S A |
89 |
1992 |
| I |
110 |
| 2TPI
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
I |
59 |
n/a |
0.200 |
2.100 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| S |
2 |
| Z |
229 |
| 3BTD
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN THE BOVINE BETA-TRYPSIN AND
TEN P1 VARIANTS OF BPTI. |
E |
223 |
7.500 |
0.195 |
1.900 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTE
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI. |
E |
223 |
7.500 |
0.196 |
1.850 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTF
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI. |
E |
223 |
7.500 |
0.194 |
1.800 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTG
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.199 |
1.900 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTH
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.204 |
1.750 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTK
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.202 |
1.850 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTM
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.199 |
1.800 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTQ
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.194 |
1.900 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTT
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.195 |
1.900 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3BTW
|
X-RAY
DIFFRACTION |
THE
CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN
P1 VARIANTS OF BPTI |
E |
223 |
7.500 |
0.191 |
2.050 |
R.Helland,
J.Otlewski, O.Sundheim, M.Dadlez, A.O.Smalas |
923 |
J.Mol.Biol. |
287 |
1999 |
| I |
58 |
| 3PTB
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
n/a |
223 |
n/a |
0.182 |
1.700 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr.,Sect.B |
39 |
1983 |
| 3PTN
|
X-RAY
DIFFRACTION |
ON
THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND
LOW-TEMPERATURE CRYSTALLOGRAPHY |
n/a |
223 |
n/a |
n/a |
1.700 |
J.Walter,
W.Steigemann, T.P.Singh, H.Bartunik, W.Bode, R.Huber |
1462 |
Acta
Crystallogr.,Sect.B |
38 |
1982 |
| 3TGI
|
X-RAY
DIFFRACTION |
WILD-TYPE
RAT ANIONIC TRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
(BPTI) |
E |
223 |
8.500 |
0.177 |
1.800 |
A.Pasternak,
D.Ringe, L.Hedstrom |
n/a |
To
be Published |
n/a |
n/a |
| I |
65 |
| 3TGJ
|
X-RAY
DIFFRACTION |
S195A
TRYPSINOGEN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) |
E |
233 |
8.000 |
0.197 |
2.200 |
A.Pasternak,
D.Ringe, L.Hedstrom |
n/a |
To
be Published |
n/a |
n/a |
| I |
65 |
| 3TGK
|
X-RAY
DIFFRACTION |
TRYPSINOGEN
MUTANT D194N AND DELETION OF ILE 16-VAL 17 COMPLEXED WITH BOVINE
PANCREATIC TRYPSIN INHIBITOR (BPTI) |
E |
231 |
8.500 |
0.184 |
1.700 |
A.Pasternak,
A.White, C.J.Jeffery, N.Medina, M.Cahoon, D.Ringe, L.Hedstrom |
1331 |
Protein
Sci. |
10 |
2001 |
| I |
65 |
| 3TPI
|
X-RAY
DIFFRACTION |
THE
GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN,
TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS |
I |
58 |
n/a |
0.193 |
1.900 |
M.Marquart,
J.Walter, J.Deisenhofer, W.Bode, R.Huber |
480 |
Acta
Crystallogr.,Sect.B |
39 |
1983 |
| S |
2 |
| Z |
229 |
| 4TPI
|
X-RAY
DIFFRACTION |
THE
REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY
COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG==15==
ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR |
I |
58 |
n/a |
0.170 |
2.200 |
W.Bode,
J.Walter, R.Huber, H.R.Wenzel, H.Tschesche |
185 |
Eur.J.Biochem. |
144 |
1984 |
| S |
2 |
| Z |
229 |
| 5PTP
|
X-RAY
DIFFRACTION |
STRUCTURE
OF HYDROLASE (SERINE PROTEINASE) |
n/a |
223 |
n/a |
0.152 |
1.340 |
J.S.Finer-Moore,
A.A.Kossiakoff, J.H.Hurley, T.Earnest, R.M.Stroud |
203 |
Proteins |
12 |
1992 |
| 8EST
|
X-RAY
DIFFRACTION |
REACTION
OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED
3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE
CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH
4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN |
E |
240 |
n/a |
0.170 |
1.780 |
J.C.Powers,
J.Oleksyszyn, S.L.Narasimhan, C.M.Kam |
3108 |
Biochemistry |
29 |
1990 |
|
