Beriberi - originating in the malfunctioning of metabolism
Pyruvate dehydrogenase:
The green cluster of spheres on the inte-rior of the cubic arrangement are the 24 E2 (dihydrolipoamide acetyltransferase) catalytic domains. The red spheres pro-jecting out from these are the lipoyllysyl domains of the E2s. The orange spheres on the "edges" of the cube represent the 24 dimeric E1s (pyruvatedehydrogenase).
The yellow spheres in the center of the "cube face" represent the 6 dimeric E3s (dihydrolipoamide dehydrogenase).
